Dendrimers and their applications

نویسندگان

چکیده

Dendrimers are symmetric molecules; their size is within the nanoscale. Its structure usually homogeneous and monodisperse; they composed of a nucleus several layers 1. The number that dendrimer has defines its generation. There different types dendrimers. synthesis these macromolecules carried out following steps growth activation, organic reactions required to obtain branched structure2. Although essential, determining factor toxicity in dendrimers charge surface; it been found higher generation cationic ones most toxic compared lower anionics evaluated at low concentrations did not show any 3. will favor pharmacokinetics drug through dendritic structure, be used, intramolecular interaction force between adjacent functional groups dendrimer, conditions environment such as pH, solvent polarity, strength ionic, saline concentration or presence counterions, among others 4. Due dendrimers' surface composition, use delivery increasingly studied. mechanisms drugs dendrimers, can broadly divided into simple encapsulation, electrostatic interaction, covalent bonds 5. ocular administration greatly impacted complexity this route. Gene therapy also benefited from emergence molecules facilitates targeted therapy.
 Keywords: Dendrimers, Drug delivery, therapy, Pharmacokinetic, Transport System

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ژورنال

عنوان ژورنال: Journal of Drug Delivery and Therapeutics

سال: 2022

ISSN: ['2250-1177']

DOI: https://doi.org/10.22270/jddt.v12i1-s.5307